About the product
CKMB (Creatine Kinase-MB) is an in vitro diagnostic reagent from Roche Diagnostics for the cobas c and COBAS INTEGRA systems. According to Roche, the test is for the quantitative determination of the catalytic activity of the creatine kinase MB subunit in human serum and plasma.
The reagent is an enzyme activity test that measures catalytic activity, not CK-MB mass. The product is part of the Roche Diagnostics test kit range supplied by Tilia Medical.
Measured parameter and clinical significance
Creatine kinase (CK) is an enzyme involved in energy production. According to MedlinePlus, CK is found mostly in skeletal muscle, in smaller amounts in the heart and in very small amounts in the brain. Damaged tissue releases more CK into the blood.
Among the CK isoenzymes, CK-MB is found mainly in heart muscle. MedlinePlus states that high CK-MB levels most likely result from damage to heart muscle, most often caused by a heart attack or inflammation of the heart muscle. Heart surgery, heart failure, hypothyroidism and kidney failure can also raise CK-MB. According to the same source, troponin tests are used more often to detect a heart attack.
MedlinePlus notes that CK has three isoenzymes: CK-MM, predominant in skeletal muscle; CK-MB, predominant in the heart; and CK-BB, predominant in the brain. Isoenzyme measurement helps identify which tissue the raised CK comes from. A CK test may be requested to evaluate muscle injuries, muscular dystrophy, rhabdomyolysis and myositis, and during statin use.
Technical information
- Measured quantity (Roche): catalytic activity of CK-MB
- Sample type (Roche): human serum and plasma
- Analyzers (Roche): cobas c 111; cobas c 303, 311, 501, 502, 503, 703; cobas c 701/702; COBAS INTEGRA 400 plus
- Pack size (Roche): 600 tests (cobas c 701/702); 150 tests (cobas c 303/503/703); 100 tests (COBAS INTEGRA 400 plus and cobas c 303/311/501/502); 2 x 50 tests (cobas c 111)
- Method principle and measuring range: not stated on the Roche product page
Use and compatibility
Roche’s product page lists the cobas c family and the COBAS INTEGRA 400 plus for CKMB; each pack is assigned to a specific analyzer group.
For product, quotation and technical information requests, use the contact form or write to info@tiliamedical.com.
Frequently asked questions
According to Roche, it measures the catalytic activity of the creatine kinase MB subunit in human serum and plasma.
The Roche page lists the cobas c 111, cobas c 303/311/501/502/503/703, cobas c 701/702 and COBAS INTEGRA 400 plus.
According to MedlinePlus, CK-MB is found mainly in heart muscle. High levels most often point to heart muscle damage, but they can also rise in other conditions.
