About the product
CREJ2 (Creatinine Jaffé Gen.2) is an in vitro diagnostic reagent from Roche Diagnostics for creatinine measurement. According to Roche’s product page, the test is used on cobas c systems for the quantitative determination of creatinine in human serum, plasma and urine.
The term Jaffé in the product name refers to the reagent family based on the Jaffé method. The page mentions a compensated method for serum and plasma for some variants. The product is part of the Roche Diagnostics test kit range supplied by Tilia Medical.
Measured parameter and clinical significance
Creatinine is a waste product formed by the use of muscles and the breakdown of some muscle tissue. According to MedlinePlus, healthy kidneys filter creatinine from the blood and remove it in urine.
Blood creatinine is used to estimate the glomerular filtration rate (eGFR). Urine creatinine is used to calculate creatinine clearance and the urine albumin-to-creatinine ratio, which helps detect kidney damage. MedlinePlus stresses that a creatinine test alone is not the best way to assess kidney function and that the result is interpreted together with other tests and factors.
According to MedlinePlus, the blood sample is drawn from a vein in the arm. Urine creatinine is mostly measured on a 24-hour collection, because the level varies during the day. The test is used in routine checkups, in evaluating signs of kidney disease, in screening people with diabetes, high blood pressure, heart disease or obesity, and in monitoring medicines that affect the kidneys.
Technical information
- Sample type (Roche): human serum, plasma and urine; coverage varies by variant and analyzer
- Analyzers (Roche): cobas c 111; cobas c 303, 311, 501, 502, 503, 701, 702, 703; COBAS INTEGRA 400 plus
- Pack size (Roche): 2500 tests (cobas c 303/503/703); 1500 tests (cobas c 701/702); 700 tests (COBAS INTEGRA 400 plus and cobas c 311/501/502); 4 x 100 tests (cobas c 111)
- Measuring range and reaction details: not stated on the Roche product page; refer to the Method Sheet
Use and compatibility
On the Roche page, CREJ2 packs are separated by analyzer group. On the COBAS INTEGRA side, serum and plasma applications and urine applications appear as separate variants. Because the page does not clearly match catalog numbers to pack sizes, confirmation against the manufacturer’s documents is needed before ordering.
For product, quotation and technical information requests, use the contact form or write to info@tiliamedical.com.
Frequently asked questions
According to Roche, it is used with human serum, plasma and urine; coverage varies by analyzer variant.
The Roche page lists 2500 tests (cobas c 303/503/703), 1500 tests (cobas c 701/702), 700 tests (COBAS INTEGRA 400 plus and cobas c 311/501/502) and 4 x 100 tests (cobas c 111).
According to MedlinePlus, blood creatinine gives information about the filtering function of the kidneys and is used to calculate eGFR. The test alone is not the best way to assess kidney function.
