About the product
LACT2 (Lactate Gen.2) is an in vitro diagnostic reagent from Roche Diagnostics for lactate measurement. According to Roche’s product page, the test is used on cobas c systems for the quantitative determination of lactate in human plasma and cerebrospinal fluid (CSF).
The cobas c 111 application is for plasma only. The product is part of the Roche Diagnostics test kit range supplied by Tilia Medical.
Measured parameter and clinical significance
Lactate is produced when muscle and red blood cells break down glucose without enough oxygen. According to MedlinePlus, a blood lactate measurement is used to diagnose lactic acidosis, assess its severity and monitor it, and to check whether cells are receiving enough oxygen.
Lactate in cerebrospinal fluid helps distinguish bacterial from viral forms when meningitis is suspected. MedlinePlus states that high CSF lactate generally points to bacterial meningitis, while normal or mildly raised values point to viral meningitis. The test does not show the cause; the result is interpreted together with symptoms and other tests.
According to MedlinePlus, the blood sample is most often taken from a vein. An arterial sample may give a more accurate result and is usually taken as part of an arterial blood gas test. A CSF sample is obtained by lumbar puncture when meningitis is suspected.
Technical information
- Sample type (Roche): human plasma and cerebrospinal fluid; plasma only for the cobas c 111
- Analyzers (Roche): cobas c 111; cobas c 303, 311, 501, 502, 503, 701, 702, 703; COBAS INTEGRA 400 plus
- Pack size (Roche): 100 tests (cobas c 303/503/703); 100 tests (COBAS INTEGRA 400 plus and cobas c 311/501/502); 225 tests (cobas c 701/702); 2 x 50 tests (cobas c 111)
- Method principle and measuring range: not given on the Roche product page; refer to the manufacturer's Method Sheet
Use and compatibility
The Roche page shows that the lactate reagent is supplied in separate packs for the cobas c family and the COBAS INTEGRA 400 plus. Because plasma and CSF applications may differ by analyzer, laboratories that will run CSF should confirm from the Method Sheet that this application is defined on the system they have chosen.
For product, quotation and technical information requests, use the contact form or write to info@tiliamedical.com.
Although the name of the cobas c 111 pack includes 100T, Roche lists its pack size as 2 x 50 tests.
Frequently asked questions
According to Roche, it works with human plasma and cerebrospinal fluid. The cobas c 111 application is for plasma only.
The Roche page lists the cobas c 111, cobas c 303/311/501/502/503/701/702/703 and COBAS INTEGRA 400 plus.
According to MedlinePlus, the test measures the lactate level in the blood. A high value can be a sign of a wide range of conditions; the test does not show the cause, and the result is interpreted by a physician.
