About the product
The cobas e 411 analyzer is Roche Diagnostics’ automated analyzer for immunochemistry tests. According to Roche, the instrument is designed to run qualitative, semi-quantitative and quantitative immunochemistry tests. The tests run on the instrument determine its field of application. Roche lists screening, monitoring, diagnosis and prognosis among its intended uses. For brand information, the Roche Diagnostics page can be consulted.
System features
Roche describes the instrument as a random-access, multichannel immunological analysis system. Measurement is based on electrochemiluminescence (ECL) technology for heterogeneous immunoassays. According to Roche’s Elecsys test method sheets, the reaction mixture is transferred to the measuring cell, the microparticles are held magnetically on the electrode surface, and unbound substances are removed. The light produced when voltage is applied is measured by a photomultiplier, and the signal is proportional to the analyte concentration.
Technical information
- Measurement principle: ECL technology for heterogeneous immunoassays (manufacturer's claim)
- Reagent positions: 18 (manufacturer's claim)
- Sample types: serum, plasma and urine in Roche's capability list. Cerebrospinal fluid, oral fluid and hemolysate also appear in the intended use statement (manufacturer's claim)
- Pipetting: single-use tips and cups that prevent carryover contamination (manufacturer's claim)
- Detection: clot and liquid level detection in samples (manufacturer's claim)
Use and compatibility
The cobas e 411 runs Roche’s Elecsys immunoassay tests. The Elecsys Vitamin B12 II and Elecsys Rubella IgM tests are listed for the cobas e 411 on Roche product pages. The FDA decision summaries also name the cobas e 411 analyzer for these tests: as the particular instrument requirement in the Elecsys Vitamin B12 II summary, and as one of the analyzers tested in the Elecsys Rubella IgM summary.
According to the Elecsys Rubella IgM summary, results are calculated with two-point calibration and the master curve provided through the reagent barcode. For higher-capacity units of the same cobas e platform, the cobas e 402 page can be consulted, and for the e 601 module in the cobas 6000 series, the cobas 6000 page.
For product, quotation and technical information requests, the form on the contact page or info@tiliamedical.com can be used.
Frequently asked questions
According to Roche, the instrument uses electrochemiluminescence (ECL) technology for heterogeneous immunoassays.
The Roche product page states 18 reagent positions. The instrument pipettes with single-use tips and cups that prevent carryover contamination.
Roche product pages list the Elecsys Vitamin B12 II and Elecsys Rubella IgM tests for the cobas e 411.
