About the product
CO2-L (Bicarbonate Liquid, Roche code CPS_000073) is an in vitro diagnostic reagent for the quantitative determination of bicarbonate (HCO3-) concentration in human serum and plasma. According to Roche Diagnostics product information, the reagent is used on cobas c systems and on the COBAS INTEGRA 400 plus.
Measured parameter and clinical significance
Bicarbonate is one of the main electrolytes measured in the blood. According to MedlinePlus, it helps maintain the body’s acid-base balance (pH). A low level is associated with acidosis, meaning an excess of acid in the blood, and a high level with alkalosis, meaning an excess of base. MedlinePlus also refers to bicarbonate as carbon dioxide (CO2) and presents it as one component of the electrolyte panel.
Interpretation of a bicarbonate result depends on the other electrolyte values and the clinical situation, and rests with the physician.
Technical information
- Product: CO2-L, Bicarbonate Liquid (Roche, CPS_000073)
- Analyte and sample: bicarbonate (HCO3-); human serum and plasma
- Method: the FDA 510(k) summary that Roche prepared for COBAS INTEGRA Bicarbonate liquid describes a ready-to-use liquid enzymatic determination containing phosphoenolpyruvate carboxylase and malate dehydrogenase. Absorbance at 409 nm decreases in proportion to the bicarbonate concentration (manufacturer's statement). Method details for cobas c systems are in the Roche method sheet
- Pack size: 2 × 100 tests (cobas c 111)
- Pack size: 250 tests and 2,300 tests (cobas c 303/503/703)
- Pack size: 700 tests and 1,100 tests (cobas c 701/702)
- For COBAS INTEGRA, the product page lists a 250-test pack
Use and compatibility
The Roche product page lists these systems for the reagent:
- cobas c 111
- cobas c 303, 503 and 703
- cobas c 311, 501 and 502
- cobas c 701 and 702
- COBAS INTEGRA 400 plus
For system pages, see cobas c 111 and cobas c 303. A system page is available for the COBAS INTEGRA 400 plus. Other reagents are in the biochemistry test kits category.
For details on calibrators, quality control and the measuring range, refer to the Roche method sheet (Method Sheet).
Frequently asked questions
According to the Roche product page, the test is defined for bicarbonate determination in human serum and plasma.
According to MedlinePlus, bicarbonate is an electrolyte that helps maintain the body’s acid-base balance and is also referred to as carbon dioxide.
The Roche product page lists the cobas c 111, cobas c 303/503/703, cobas c 311/501/502, cobas c 701/702 and COBAS INTEGRA 400 plus systems.
Contact
For product, quotation and technical information requests, use the contact form or write to info@tiliamedical.com.
